By M. Ola
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Additional info for Diabetic Retinopathy
2008 Jun 12;358(24):2560-2572.  Pazdro R, Burgess JR. The role of vitamin E and oxidative stress in diabetes complications. Mech Ageing Dev. 2010 Apr;131(4):276-86.  Peng PH, Lin HS, Lin S. Nerve fibre layer thinning in patients with preclinical retinopathy. Can J Ophthalmol. 2009 Aug;44(4):417-22.  Petrovič MG, Korošec P, Košnik M, Hawlina M. Association of preoperative vitreous IL-8 and VEGF levels with visual acuity after vitrectomy in proliferative diabetic retinopathy. Acta Ophthalmol.
Immune-mediated (Type I) diabetes results from an organ-specific autoimmune-mediated loss of insulin-secreting β cells. This chronic destruction process involves both cellular and hormonal components detectable in the peripheral blood, months or even years, before the onset of clinical diabetes (Kukreja & Maclaren 1999). In order to elicit an immune response, a molecule must be recognized as non-self by the biological system. , 1996). , 1992). , 1995). However, it is still not known whether one of these compounds contributes, as a major AGE structure, to the pathogenesis of these diseases, or whether other structures may involve in this process.
2008 May-Jun;71(3):459-63.  Sheikpranbabu S, Haribalaganesh R, Lee KJ, Gurunathan S. Pigment epitheliumderived factor inhibits advanced glycation end products-induced retinal vascular permeability. Biochimie. 2010 (a), 92(8):1040-51.  Sheikpranbabu S, Ravinarayanan H, Elayappan B, Jongsun P, Gurunathan S. Pigment epithelium-derived factor inhibits vascular endothelial growth factor-and interleukin-1beta-induced vascular permeability and angiogenesis in retinal endothelial cells. Vascul Pharmacol.
Diabetic Retinopathy by M. Ola