By Chi-Chao Chan
This e-book describes experimental animal versions that mimic universal human ocular illnesses: herpetic keratitis, cataract, glaucoma, age-related macular degeneration, diabetic retinopathy, uveitis, retinitis pigmentosa, Graves’ disorder, and intraocular tumors. In conjunction, those types mirror the variety and application of instruments used to check human affliction. international specialist clinicians talk about each one version in response to their medical adventure and the textual content is supported via quite a few images and diagrams. In describing the main pertinent animal versions of ophthalmic illnesses, this booklet may be of curiosity to ophthalmologists, imaginative and prescient researchers, fellows, citizens and clinical students.
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Extra info for Animal Models of Ophthalmic Diseases
Diabetes Obes Metab 5(2):113–119 Hejtmancik JF (2008) Congenital cataracts and their molecular genetics. Seminars Cell Dev Biol 19(2):134–149. 003 Horwitz J (2003) Alpha-crystallin. , Kinoshita JH (1980) Philly mouse: a new model of hereditary cataract. Exp Eye Res 30(1):59–68 Kador PF, Sun G, Rait VK, Rodriguez L, Ma Y, Sugiyama K (2001) Intrinsic inhibition of aldose reductase. J Ocul Pharmacol Ther: The Official J Assoc Ocular Pharmacol Therapeutics 17(4):373–381. 1089/108076801753162780 Kador PF, Betts D, Wyman M, Blessing K, Randazzo J (2006) Effects of topical administration of an aldose reductase inhibitor on cataract formation in dogs fed a diet high in galactose.
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Another related cataract, fibrotic cataract, is anterior subcapsular cataract (ASC). ASCs are much less common but can be induced in a pathological situation, that is, it can occur after ocular trauma, surgery, or systemic diseases such as atopic dermatitis and retinitis pigmentosa. Unlike PCO, ASCs are primary cataracts that occur when anterior LECs, in situ, are stimulated to transition into myofibroblasts (Font and Brownstein 1974; Novotny and Pau 1984). In vivo models of TGFβ-induced ASCs have also been developed, including a transgenic mouse model in which active TGFβ is ectopically expressed in lens fiber cells under the control of the αA-crystallin promoter (Srinivasan et al.
Animal Models of Ophthalmic Diseases by Chi-Chao Chan