By G. Hasko
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Extra resources for Adenosine Receptors - Therapeutic Asps. for Inflamm., Immune Diseases
5. G. , N6-Substituted adenosine derivatives: selectivity, efficacy, and species differences at A3 adenosine receptors, Biochem. , 65, 1675, 2003. 6. A. , Purine receptors: GPCR structure and agonist design, Mol. , 4, 337, 2004. 7. P. , The synthesis of new adenosine A3 selective ligands containing bioisosteric isoxazoles, Bioorg. Med. Chem. , 13, 1767, 1998. 8. Vittori, S. , N-cycloalkyl derivatives of adenosine and 1-deazaadenosine as agonists and partial agonists of the A1 adenosine receptor, J.
Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype, J. Med. , 39, 4142, 1996. 41. Colotta, V. , 1,2,4-triazolo[4,3-a]quinoxalin-1-one moiety as an attractive scaffold to develop new potent and selective human A3 adenosine receptor antagonists: synthesis, pharmacological, and ligand-receptor modeling studies, J. Med. , 47, 3580, 2004. 42. Catarzi, D. , 2-aryl-8-chloro-1,2,4-triazolo[1,5-a]quinoxalin-4-amines as highly potent A1 and A3 adenosine receptor antagonists, Bioorg.
3 Note: The compound numbers correspond to numbers used in the text and schemes. a Binding experiments at recombinant human A1, A2A, and A3ARs, unless noted. Values expressed as Ki (nM) ± SEM, except when a percentage is indicated, which means inhibition percentage of binding at 10 µM. b Binding and functional experiments at rat ARs. fm Page 22 Wednesday, May 24, 2006 3:00 PM 22 Adenosine Receptors adenosines were full (4 or 5 carbons) or partial (6 carbons) hA3AR agonists. 9 and 106 nM, respectively).
Adenosine Receptors - Therapeutic Asps. for Inflamm., Immune Diseases by G. Hasko